Of course, the biggest villain in Salem history has to beStefano DiMera(Joseph Mascolo).

Stefano brought his nephew Andre to town in hopes of helping him run his empire.

Stefano then had Tony imprisoned so that Andre could assume his identity.

Thaao Penghlis on the red carpet.

Andre and Stefano then began to wreak havoc upon Salem (viaSoap Central).

This led to the real Roman being put in jail, perSoaps.

Eventually, Anna found Tony and figured out what was going on.

Thaao Penghlis smiles for the camera.

However, Andre captured her and locked her away as well (viaSoap Hub).

Eventually, Roman was able to save Tony and Anna.

Roman’s hero act created chaos with Andre and the two men began to fight.

Days of Our Lives stars Leann Hunley and Thaao Penghlis.

However, during their duel, Andre slipped away and eventually fled Salem.

Andre headed to a secret compound on Stefano’s island where they began to devise their next devious plan.

This caused the plane to crash on a remote island.

Thaao Penghlis at an event.

Tony’s mother Daphne died in the crash, which led to a fight between Andre and Tony.

During the scuffle, Andre was believed to have died in quicksand.

However, Andre lived and returned to Stefano to begin plotting his revenge, perSoaps.

Thaao Penghlis and Matthew Ashford of Days of Our Lives.

After Andre was presumed dead, Tony went back to Salem.

In 1985, he opted to leave the fictional midwestern town but was intercepted by Stefano and Andre.

With Tony no longer a threat, Andre was free to assume his identity yet again.

Thaao Penghlis and Days of Our Lives co-star Kate Mansi at an event.

Posing as Tony, Andre was ready to marry his fiancee, Kristen Blake.

However, Kristen was really in love with John Black.

After the couple’s wedding, many Salemites headed to Louisiana for a charity event.

The house exploded and left him blind.

However, his plan was later foiled when someone got a hold of his diary.

John was cleared of the murder charges and everyone in Salem believed that he was gone.

Seven years passed before Andre resurfaced in Salem still using Tony’s identity.

He came back to town to crash John and Marlena’s anniversary party.

Bo Brady confronted Tony, who then admitted that he had been Andre the entire time.

Andre later fled Salem again, but he wasn’t done scheming, perSoap Central.

According toSoap Hub, Andre returned in 2015 when he demanded to be named the CEO of DiMera Enterprises.

He also brainwashed his brother Chad DiMera so that he would kill both Hope and Rafe.

Andre also had a brief fling with Kate Roberts after his return to Salem.

However, Andre’s time in Salem was cut short when he was found murdered in an office.

It was later discovered thatAbigail Deveraux-DiMera had killed Andre while suffering from a split personality disorder.

Andre was considered dead for good this time around.